发明名称 |
Single-chain beta subunit dimers of the glycoprotein hormones and recombinant materials related thereto |
摘要 |
Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. In one embodiment of these single-chain forms, the alpha and beta subunits of the wild-type heterodimers or their variants are covalently linked, optionally through a linker moiety. A drug may further be included within the linker moiety to be targeted to receptors for these hormones. Some of the single-chain forms are agonists and others antagonists of the glycoprotein hormone activity. Another embodiment of the single-chain compounds of the invention comprises two beta subunits of the glycoprotein hormones, which beta subunits are the same or different. These "two- beta " forms are antagonists of glycoprotein hormone activity.
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申请公布号 |
US5958737(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19970806772 |
申请日期 |
1997.02.26 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
BOIME, IRVING;BEN-MENAHEM, DAVID |
分类号 |
A61K38/00;C07K14/575;C07K14/59;C12N;C12N15/16;(IPC1-7):C12N15/16;C07H21/00 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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地址 |
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