METHODS, DEVICES, AND COMPOSITIONS FOR LYSIS OF OCCLUSIVE BLOOD CLOTS WHILE SPARING WOUND SEALING CLOTS

摘要

Various mutant forms of pro-urokinase ("pro-UK") perform in the manner of pro-UK in lysing "bad" blood clots (those clots that occlude blood vessels), while sparing hemostatic fibrin in the so-called "good" blood clots (those clots that seal wounds, e.g., after surgery or other tissue injury). Thus, these pro-UK mutants are excellent and safe thrombolytic agents. These advantages allow them to be used in a variety of new methods, devices, and compositions useful for thrombolysis and treating various cardiovascular disorders in clinical situations where administration of othe r known thrombolytic agents has been too risky or even contraindicated.