发明名称 |
Human smad3 and smad4 are sequence-specific transcription activators |
摘要 |
Two human Smad proteins (Smad3 and Smad4) specifically recognize an identical 8 bp palindromic sequence (GTCTAGAC) (SEQ ID NO: 1). Tandem repeats of this palindrome confer striking TGF- beta responsiveness to a minimal promoter. This responsiveness is abrogated by targeted deletion of the cellular Smad4 gene. DNA molecules comprising the 8 bp palindromic sequence can be used in assays for drug screening and diagnostically. |
申请公布号 |
AU3084099(A) |
申请公布日期 |
1999.09.27 |
申请号 |
AU19990030840 |
申请日期 |
1999.03.12 |
申请人 |
THE JOHNS-HOPKINS UNIVERSITY |
发明人 |
SCOTT E. KERN;LEIGH ZAWEL;JIA LE DAI;BERT VOGELSTEIN;KENNETH W. KINZLER |
分类号 |
C07K14/47;C12N15/12;C12Q1/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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