Human monoclonal antibodies against human cytokines and methods of making and using such antibodies

摘要

PCT No. PCT/US94/13188 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 21, 1994 PCT Pub. No. WO95/14780 PCT Pub. Date Jun. 1, 1995Human monoclonal antibodies against a human cytokine (such as a human interleukin, e.g., human IL-1 alpha ) and fragments of such antibodies are disclosed. Also disclosed are pharmaceutical compositions and methods employing the human monoclonal antibodies and fragments, methods for screening for human monoclonal antibodies against a human protein, methods for producing a cDNA library enriched in DNA encoding VH and/or VL chains of a human monoclonal antibody, cell lines for making the human monoclonal antibodies, and isolated DNA for making the human monoclonal antibodies and fragments of the invention.