发明名称 |
METHODS FOR ENHANCED ANTIGEN PRESENTATION ON ANTIGEN-PRESENTING CELLS AND COMPOSITIONS PRODUCED THEREBY |
摘要 |
The present invention provides compositions and methods for immunotherapy, and in particular for inducing an immune response against an antigen in a patient. Thus, in one aspect, this invention provides genetically modified antigen-presenting cells which are more potent presenters of exogenous peptide than parental antigen-presenting cells. Compositions comprising these genetically modified cells and a carrier, such as pharmaceutically acceptable carrier, are further provided by this invention. The genetically modified antigen-presenting cells of this invention can be used in adoptive immunotherapy or to expand a substantially pure population of immune effector cells. Methods for expansion of the substantially pure population of cells are also provided by this invention. |
申请公布号 |
WO9947102(A2) |
申请公布日期 |
1999.09.23 |
申请号 |
WO1999US06031 |
申请日期 |
1999.03.19 |
申请人 |
GENZYME CORPORATION;NICOLETTE, CHARLES, A.;KAPLAN, JOHANNE |
发明人 |
NICOLETTE, CHARLES, A.;KAPLAN, JOHANNE |
分类号 |
C12N15/09;A61K35/26;A61K35/28;A61K48/00;A61P37/02;A61P37/04;C12N5/0784 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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