The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumour prodrugs and those which are specifically activated by the hydroxylation activity of the P-450 enzyme CYP1B1. Also provided are methods of detection of aromatic oxidation activity.
申请公布号
WO9940944(A3)
申请公布日期
1999.09.23
申请号
WO1999GB00416
申请日期
1999.02.10
申请人
DE MONTFORT UNIVERSITY;POTTER, GERARD, ANDREW;PATTERSON, LAWRENCE, HYLTON;BURKE, MICHAEL, DANNY
发明人
POTTER, GERARD, ANDREW;PATTERSON, LAWRENCE, HYLTON;BURKE, MICHAEL, DANNY
