发明名称 |
BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS |
摘要 |
Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N-oxide; R1 and R2 are substituents as defined within; R3 and R4 are defined within and are alkyl or halo alkyl or together form a cycloalkyl or halocycloalkyl ring; R5 is a substituent as defined within; Y-Z is a linking group as defined within; are useful in the production of an elevation of PDH activity in a warm-blooded animal such as a human being. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are described.
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申请公布号 |
CA2323783(A1) |
申请公布日期 |
1999.09.23 |
申请号 |
CA19992323783 |
申请日期 |
1999.03.11 |
申请人 |
ASTRAZENECA AB |
发明人 |
BURROWS, JEREMY NICHOLAS;CLARKE, DAVID STEPHEN;WHITTAMORE, PAUL ROBERT OWEN;NOWAK, THORSTEN;BUTLIN, ROGER JOHN |
分类号 |
C07D295/12;A61K31/18;A61K31/341;A61K31/357;A61K31/36;A61K31/381;A61K31/40;A61K31/403;A61K31/404;A61K31/4164;A61K31/426;A61K31/433;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/445;A61K31/4453;A61K31/495;A61K31/4965;A61K31/505;A61K31/5375;A61K31/54;A61P3/06;A61P3/10;A61P9/10;A61P21/04;A61P25/28;A61P43/00;C07C311/46;C07C311/51;C07C311/58;C07C311/60;C07C317/34;C07C319/20;C07C323/49;C07C323/62;C07D207/48;C07D209/08;C07D209/30;C07D211/22;C07D211/46;C07D211/56;C07D211/96;C07D213/42;C07D213/76;C07D233/61;C07D239/42;C07D239/48;C07D241/20;C07D241/22;C07D243/08;C07D261/16;C07D277/04;C07D277/06;C07D285/06;C07D295/13;C07D295/18;C07D295/192;C07D295/22;C07D295/26;C07D307/14;C07D307/22;C07D307/24;C07D317/58;C07D333/20;C07D333/38;C07D333/40;C07D521/00;(IPC1-7):C07D295/22 |
主分类号 |
C07D295/12 |
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