发明名称 |
MONOCLONAL ANTIBODIES SPECIFIC FOR THE EXTRACELLULAR DOMAIN OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN |
摘要 |
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.
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申请公布号 |
CA2323096(A1) |
申请公布日期 |
1999.09.23 |
申请号 |
CA19992323096 |
申请日期 |
1999.03.18 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
HOLMES, ERIC H.;TINO, WILLIAM THOMAS;MURPHY, GERALD P.;BOYNTON, ALTON L. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61P13/08;A61P35/00;C07K14/705;C07K16/28;C12N15/02;C12P21/08;C12Q1/26;C12R1/91;(IPC1-7):C12N15/12;A61K51/00;C07K14/00;C07K16/00;C07K19/00;C12N5/12;C07K16/18;A61K47/48;G01N33/554;G01N33/60 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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