IDENTIFICATION OF FACTORS WHICH MEDIATE THE INTERACTION OF HETEROTRIMERIC G PROTEINS AND MONOMERIC G PROTEINS

摘要

Monomeric GTPase guanine nucleotide exchange factor (GEF) have been identified which also contain an RGS region analogous to those of GTPase activating proteins (GAP). One of these GEF proteins, a Rho GEF has been demonstrated to contain an RGS sequence that has GAP activity toward a .alpha. subunit of a heterotrimeric G prote in.