PROCESS FOR PRODUCING L-VALINE BENZYL ESTER P-TOLUENESULFONATE

摘要

A process for producing L-valine benzyl ester p-toluenesulfonate which involves the steps of reacting L-valine with benzyl alcohol in at least one aromatic solvent selected from among toluene, monochlorobenzene and xylene in the presence of p-toluenesulfonic acid under azeotropic dehydration conditions and crystallizing L-valine benzyl ester p-toluenesulfonate from the liquid reaction mixture thus obtained. Use of this process makes it possible to safely, conveniently and industrially advantageously produce L-valine benzyl ester p-toluenesulfonate which is appropriately usable as an intermediate of drugs such as remedies for hypertension.