| 摘要 |
A method for lubricating a sealing member (54) and a medicament chamber (44) in a drug delivery device includes providing lubricating silicone on the surface of the sealing member (54). The sealing member (54) preferably is first washed and rinsed in hot deionized water followed by drying. The dried sealing member is then tumbled with polymeric silicone and then irradiated at a target dose between 2.5 to 4.0 Mrads to cause the silicone molecules to bond with the elastomeric material of the sealing member. The irradiated sealing members are then loaded in any of a series of chambers including syringes (44), pre-filled syringes, drug cartridges (70), and needleless injector ampules (142). The chamber preferably is made from glass or a plastic material that has been mixed with a lubricating solution such as silicone when the plastic is compounded.
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