摘要 |
Heteroaromatic derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein Z represents a group represented by general formula (II), (III), (IV) or (V) (wherein Ar<1> represents phenyl optionally substituted by a halogen or C1-5 alkyl; R<2> represents a C1-5 alkyl; and Y represents hydrogen, mercapto, a C1-5 alkylthio, or amino optionally substituted by one or two C1-5 alkyls); Ar<2> represents phenyl optionally having one or two substituents selected among halogens, C1-5 alkyls, C1-5 alkoxys, hydroxy, and trifluoromethyl; B<1>-B<2> represents CH-CO or C=C(R<1>) (wherein R<1> represents hydrogen or a C1-5 alkyl); and n is an integer of 1 to 4. The compounds are dopamine D4 receptor antagonists having a psychotropic action without causing extrapyramidal disorders.
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申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;NIHON NOHYAKU CO., LTD.;NAKAZATO, ATSURO;KUMAGAI, TOSHIHITO;CHAKI, SHIGEYUKI;TOMISAWA, KAZUYUKI;NAGAMINE, MASASHI;GOTOH, MAKOTO;YOSHIDA, MASANORI |
发明人 |
NAKAZATO, ATSURO;KUMAGAI, TOSHIHITO;CHAKI, SHIGEYUKI;TOMISAWA, KAZUYUKI;NAGAMINE, MASASHI;GOTOH, MAKOTO;YOSHIDA, MASANORI |