发明名称 |
CARRIER FOR IN VIVO DELIVERY OF A THERAPEUTIC AGENT |
摘要 |
A carrier for in vivo delivery of a therapeutic agent comprising a thiol group is provided, wherein the therapeutic agent is conjugated to the carrier via a biodegradable disulfide bond. Since extracellular fluids in vivo do not provide the appropriate environment to efficiently reduce a disulfide bond, while cellular cytosol does provide an appropriate environment, the agent will remain substantially coupled to the carrier while circulating through the body until the carrier crosses a cell membrane. As a result, the therapeutic agent is protected from degradation and renal clearance, and the potential for the therapeutic agent to elicit an immune response is limited. |
申请公布号 |
WO9947173(A2) |
申请公布日期 |
1999.09.23 |
申请号 |
WO1999US05914 |
申请日期 |
1999.03.19 |
申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
STEIN, STANLEY;LEIBOWITZ, MICHAEL, J. |
分类号 |
A61K38/00;A61K45/00;A61K47/20;A61K47/48;A61P31/12;A61P43/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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