ENHANCED BIOCOMPATIBILITY COATINGS FOR MEDICAL IMPLANTS

摘要

Enhanced biocompatibility coatings for medical implants and acute exposure medical devices are disclosed in conjunction with methods for their production and use. The biocompatible coatings are particularly advantageous when used in conjunction with high surface area materials such as porous resins, fabrics and textiles and comprise ionically bound complexes of at least one anticlotting compound and at least one quaternary ammonium compound having greater than 0.15 and less than 40 IU of anticlotting compound per CM<2>. The coatings are produced by forming a solution of the complex having a concentration greater than 0.005 % and less than 1.5 % w/v which is applied to the surface and allowed to dry. The coatings reduce the propensity for thrombus deposition without impairing healing and tissue ingrowth into the device.