发明名称 |
THERAPEUTIC CHEMOKINE RECEPTOR ANTAGONISTS |
摘要 |
The invention provides a variety of therapeutic uses for CXCR4 antagonists. In various embodiments, CXCR4 antagonists may be used as therapeutically as follows, or to manufacture a medicament for such therapeutic treatments: reducing interferon gamma production by T-cells, treatment of an autoimmune disease, treatment multiple sclerosis, treatment of cancer, inhibition of angiogenesis. The invention provides corresponding methods of medical treatment, in which a therapeutic dose of a CXCR4 antagonist is administered in a pharmacologically acceptable formulation. Accordingly, the invention also provides therapeutic compositions comprising a CXCR4 antagonist and a pharmacologically acceptable excipient or carrier. The CXCR4 antagonists for use in the invention may be peptide compounds comprising a substantially purified peptide fragment, modified fragment, analogue or pharmacologically acceptable salt of SDF-1. |
申请公布号 |
WO9947158(A2) |
申请公布日期 |
1999.09.23 |
申请号 |
WO1999CA00221 |
申请日期 |
1999.03.12 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA;CLARK-LEWIS, IAN;GONG, JIANG-HONG;DURONIO, VINCENT |
发明人 |
CLARK-LEWIS, IAN;GONG, JIANG-HONG;DURONIO, VINCENT |
分类号 |
A61K38/00;A61K38/17;A61P9/00;A61P25/00;A61P25/28;A61P35/00;A61P37/06;A61P43/00;C07K14/00;C07K14/52;C07K14/715 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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