| 摘要 |
<p>Tablets quickly disintegrating in the oral cavity which contain drugs, saccharides (A) and amorphous saccharides (B) and are produced by molding and then drying under moistening. More particularly, tablets obtained by dissolving the drugs, the saccharides (A) and the saccharides (B) which are in a crystalline state and can be converted into amorphous ones in a pharmaceutically acceptable solvent, then eliminating the solvent from the resultant solution followed by drying, molding the obtained mixture containing the amorphous saccharides (B), and then drying the same under moistening. In the production process of these tablets, the amorphous saccharides are irreversibly converted into crystalline ones after the step of drying under moistening. Thus, these tablets are stable to moisture during storage and can maintain a constant tablet stability. In these tablets, moreover, the above-mentioned saccharides and the amorphous saccharides can be produced from saccharides of a single type, which enables preparation design with a consideration of the stability of drugs. Furthermore, these tablets makes it possible to provide a production process with the use of conventional granulators and tabletting machines.</p> |
