| 摘要 |
<p>The invention provides a fusion protein including a reporter polypeptide linked to a linker polypeptide comprising a protease cleavage site, and a repressor polypeptide that represses the activity of the reporter polypeptide. The repressor polypeptide is operatively linked to the linker polypeptide. Cleavage of the linker polypeptide at the protease cleavage site increases the activity of said reporter. A method is also provided for identifying a protease that recognizes a specific protease cleavage site. The invention further provides a method of identifying a compound that activates a protease.</p> |
