发明名称 |
METHODS FOR TREATING HIV-ASSOCIATED DEMENTIA |
摘要 |
The HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte chemoattractant protein-1. Monocyte chemoattractant protein-1 (MCP-1) is expressed in the brains of patients with HIV-1-associated dementia, and is present in the cerebrospinal fluid of patients with this condition. This present invention employs compounds, such as MCP-1 antagonists and partial agonists, as well as HIV-1 Tat-inhibitors in methods for treating and/or preventing HIV-1 associated dementia.
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申请公布号 |
WO9946991(A1) |
申请公布日期 |
1999.09.23 |
申请号 |
WO1999US05610 |
申请日期 |
1999.03.17 |
申请人 |
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE;GARZINO-DEMO, ALFREDO |
发明人 |
GARZINO-DEMO, ALFREDO |
分类号 |
A61K38/19;G01N33/68;(IPC1-7):A01N61/00;A01N37/18;A01N43/04;C12Q1/00;C12Q1/68;G01N33/53 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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