| 摘要 |
PROBLEM TO BE SOLVED: To provide a hew separated polypeptide composed of a Frizzled-3 polypeptide containing a sequence having high identity to a specific amino acid sequence over the whole length of the sequence and useful, for the treatment, diagnostic assay, etc., for neurotic diseases, etc., such as schizophrenia. SOLUTION: This separated new Frizzled-3 polypeptide contains an amino acid sequence having an identity of >=99% to the amino acid sequence of formula over the whole length of the formula and is useful for the treatment, diagnosis, etc., for neurological disorder, especially schizophrenia, dipolar/monopolar disorder, Alzheimer's disease, epilepsy, tonic paraplegia-5A, cancer, cardiovascular disease, apoplexy, developmental disorder such as Werner's syndrome, etc. The polypeptide can be produced by a standard cloning and screening technique by preparing a polynucleotide from a cDNA library originated from human neuron using EST analysis, integrating the polynucleotide into an expression system, introducing into a host cell and culturing the host cell. |
