发明名称 |
Biosensor device and method |
摘要 |
A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil-coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.
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申请公布号 |
US5955379(A) |
申请公布日期 |
1999.09.21 |
申请号 |
US19970845659 |
申请日期 |
1997.04.24 |
申请人 |
MCGILL UNIVERSITY;PENCE |
发明人 |
LENNOX, R. BRUCE;HODGES, ROBERT S.;IRVIN, RANDALL T.;ARMSTRONG, GLEN;BUNDLE, DAVID R.;KITOV, PAVEL;RAILTON, CRAIG |
分类号 |
C12Q1/00;G01N33/543;(IPC1-7):G01N33/533 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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