发明名称 |
Assay systems using the CNTF signal transduction pathway |
摘要 |
The present invention provides for a stable, biologically active CNTF/receptor complex, and hybrids or mutants thereof. The invention is also based in part on the discovery that the CNTF/receptor complex promotes differentiation through a signal transduction pathway on target cells that do not express the CNTF receptor. The invention further provides for a specific CNTFR mutant that promotes signal transduction without binding CNTF. The invention also provides for a CNTF/receptor blocking mutant, a mutant possessing a high binding affinity to CNTF, but possessing no signal transducing function. The present invention also identifies receptor components shared by the IL-6, CNTF, LIF and OSM signal transduction pathways, and the assay systems based on the use of such components.
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申请公布号 |
US5955290(A) |
申请公布日期 |
1999.09.21 |
申请号 |
US19960603010 |
申请日期 |
1996.02.16 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
STAHL, NEIL;YANCOPOULOS, GEORGE D.;IHLE, JAMES N. |
分类号 |
C12Q1/00;(IPC1-7):C12Q1/00 |
主分类号 |
C12Q1/00 |
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地址 |
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