RAS P21-interacting protein (RGL) and its RAS interacting domain (RID)

摘要

A novel protein which interacts with ras p21, has been identified. This protein, RGL, shares 69% amino acid homology with ral guanine nucleotide dissociation stimulator (ralGDS). ralGDS was also found to bind ras p21. The ras p21-interacting domain of RGL (RID) bound to ras p21 through the effector loop of ras p21. Polypeptide and polynucleotide compositions of the RGL protein are provided as well as methods for implementing the diagnostic and therapeutic uses of these compositions. The uses include isolating effector proteins of ras p21 and modulating ras activity.