| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a method for rapidly and efficiently preparing enamines without forming a coprosuct by using cheap low toxic amines having N-H bond, and terminal acetylene compounds as raw materials and reacting the raw materials in the presence of a ruthenium complex. SOLUTION: (A) An amine (e.g. N-methylaniline) having at least one N-H bond and N atom having H, an alkyl or the like as a substituent, or forming a cyclic compound containing N atom, having one N-H bond and a substituent selected from an alkylene, aralkylene or the like is reacted with (B) a terminal acetylene compound (e.g. phenylacetylene) in the presence of (C) a ruthenium complex (preferably a complex containing an organic ligand, e.g. dodecacarbonyltriruthenium) to provide (D) the objective enamine [e.g. N-methyl- N-(α-styryl)aniline] in the method for preparing the enamines. As a result, the enamines useful as synthetic raw materials for fine chemicals are provided by one step.</p> |
