发明名称 |
Antagonists of G-protein-coupled receptor |
摘要 |
The present invention relates to a new class of G-protein-coupled receptor antagonists which bind to the intracellular molecular interface between the receptor and the G-protein, thus hampering signal transduction. The present invention describes peptide sequences derived from the prostaglandin receptor F2 alpha and the G-protein, G alpha q protein, produced by molecular biology techniques or chemical synthesis, as selective inhibitors of signal transduction involved in the stimulation of this receptor. Such peptides or molecules derived from their primary, secondary and tertiary structures may be used as effective tocolytics for the prevention of premature labor or be utilized for the treatment of dysmenorrhea.
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申请公布号 |
US5955575(A) |
申请公布日期 |
1999.09.21 |
申请号 |
US19970995927 |
申请日期 |
1997.12.22 |
申请人 |
HOPITAL SAINTE-JUSTINE |
发明人 |
PERI, KRISHNA G.;CHEMTOB, SYLVAIN;POTIER, MICHEL |
分类号 |
A61K38/00;C07K14/47;C07K14/705;(IPC1-7):A61K38/04;A61K38/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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