METHOD OF PREPARING EPOXIDE

摘要

FIELD: organic synthesis. SUBSTANCE: method of preparing epoxide with formula I: <EMI ID=0.492 HE=36 WI=36 TI=CHI> (I) includes following steps: (i) interaction of 1 equivalent of compound with formula II: <EMI ID=0.493 HE=36 WI=33 TI=CHI> (II) with 1-2 equivalents of halogenation agent at temperature from -40 to -100 C in solvent mixed with aqueous solution of weak base and (ii) cyclization halohydrin with formula III: <EMI ID=0.494 HE=36 WI=39 TI=CHI> (III) prepared in step (i) by adding base in solvent. Compound I is a new intermediate utilized in synthesis of human HIV protease inhibitors. EFFECT: extended range of compounds useful in synthesis of anti-aids preparations. 6 cl, 11 ex