发明名称 Membrane pore inhibiting agents for treating infection
摘要 The invention relates to methods for identifying antimicrobial agents which inhibit bacterial toxin membrane pore formation and for treating diseases where bacterial protein toxins that form pores in membranes are virulence agents. The invention involves screening for small molecule agents which inhibit membrane pore formation by bacterial protein toxins. The invention is also a method for treating bacterial infection by inhibiting membrane pore formation by bacterial toxin using agents that inhibit membrane pore formation by bacterial toxins. The methods of the invention are also applicable for developing antiviral agents that treat viral infection where exposure of hydrophobic sites of proteins is associated with infection.
申请公布号 AU2668799(A) 申请公布日期 1999.09.20
申请号 AU19990026687 申请日期 1999.02.10
申请人 THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK 发明人 ERWIN LONDON;JUANITA C. SHARPE
分类号 A61K31/00;A61K31/185;A61K31/53;A61K31/655;C12Q1/18;G01N33/94 主分类号 A61K31/00
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