| 摘要 |
The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD-(X-Y-ONH<SUB>2</SUB>)<SUB>n</SUB>, wherein CD is mono- or polydeoxy alpha-, beta-, or gamma-cyclodextrin, carrying in its 6-, 3- and/or 2-position a group containing the aminooxy group, and optionally carrying substituents different from (X-Y-ONH<SUB>2</SUB>). Y is a linker group between the aminooxy group and the mono- or polydeoxy-CD group, X is a functional group or an atom necessary to connect the linker Y and the deoxy CD group, or Y is a direct bond when X is a direct bond, and n is >=1, but <=24, 21 and 18 for alpha-, beta- or gamma-cyclodextrin, respectively, the protected aminooxy derivatives thereof, as well the methods for their preparation and use. |
