USE OF 14-3-3 PROTEINS AS SENSITIVE BIOLOGICAL MARKERS FOR DETECTING POLLUTION CAUSED, INTER ALIA, BY POLYCHLORINATED BIPHENYL (PCB) AND (XENO)OESTROGEN AND METHOD FOR QUICK DETERMINATION OF 14-3-3 PROTEINS

摘要

The invention concerns (1) the use of a novel biological marker, namely one or several 14-3-3 proteins, for detecting the load in fresh water, sea water, drinking water or soil samples of natural and anthropogenic chemical products derived from the environment, in particular of polychlorinated biphenyl (PCB) and/or in oestrogen/xenooestrogen [(xeno)oestrogen] and (2) a novel method (ELISA method) for measuring qualitatively and quantitatively 14-3-3 proteins. Said ELISA method can also be used for detecting the occurrence of 14-3-3 protein in human and animal physiological liquids infected by the pathogenic agent responsible for prion diseases.