COMPUESTOS DERIVADOS DE PIRROLIDINA SUSTITUIDAS, INHIBIDORES DE PROTEASA ACTIVADORA DE CANAL; COMPOSICION FARMACEUTICA; Y USO PARA EL TRATAMIENTO DE ENFERMEDADES TALES COMO FIBROSIS QUISTICA, BRONQUITIS CRONICA, EPOC, ASMA E INFECCIONES DE LAS VIAS R

摘要

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.