| 发明名称 |
ALK-1 RESPONDS TO TGF- beta AND SIGNALS THROUGH SMAD-1 AND SMAD-5 |
| 摘要 |
The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF- beta family. The molecule has a role in the phosphorylation of Smad-5 and Smad-1, which also act as activators of certain genes. Aspects of the invention relate to this interaction.
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| 申请公布号 |
WO9946386(A1) |
申请公布日期 |
1999.09.16 |
| 申请号 |
WO1999US05735 |
申请日期 |
1999.03.12 |
| 申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
MIYAZONO, KOHEI;IMAMURA, TAKESHE;TEN DIJKE, PETER |
| 分类号 |
A61K38/00;C07K14/71;C07K16/28;C12N15/12;(IPC1-7):C12N15/12;A61K38/18;A61K38/17;A61K39/395;G01N33/50;C12Q1/68 |
主分类号 |
A61K38/00 |
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