VACCINES AGAINST CIRCOVIRUS INFECTIONS

摘要

Vaccine compositions which are protective against circovirus infections, including porcine circovirus and psittacine beak and feather disease virus, in animals, comprising a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an animal circovirus polypeptide, wherein the nucleic acid lacks a viral origin of replication are disclosed. Nucleic acid vectors for the transient expression of one or more circovirus polypeptides in a eukaryotic cell comprising a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to the nucleic acids of the invention are described. Methods of preventing a circovirus-associated disease in an animal comprising administering to the animal a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an animal circovirus polypeptide, wherein the nucleic acid lacks a viral origin of replication are also described. Methods of preventing a circovirus-associated disease in an animal comprising administering to the animal an immunogenic amount of one or more animal circovirus polypeptides are also described. Also disclosed are nucleic acid and polypeptide sequences useful in the vaccine compositions and methods of the invention.