发明名称 |
Transgenic rabbit that expresses a functional human lipoprotein (A). |
摘要 |
A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression. |
申请公布号 |
ZA9900133(B) |
申请公布日期 |
1999.09.16 |
申请号 |
ZA19990000133 |
申请日期 |
1999.01.08 |
申请人 |
RHONE-POULENC RORER PHARMACEUTICALS INC. |
发明人 |
DIDIER ROUY;NICOLAS DUVERGER;FLORENCE EMMANUEL;PATRICE DENEFLE;LOUIS-MARIE HOUDEBINE;CELINE VIGLIETTA;EDWARD M. RUBIN;STEVEN D. HUGHES |
分类号 |
A01K67/027;A61K49/00;C07K14/775;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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