Benzocyclobutane compounds, a process for their preparation and pharmaceutical compositions containing them.

摘要

Benzocyclobutane derivatives (I) are new. Benzocyclobutane derivatives of formula (I) and their isomers and acid-addition salts are new: Z1-Z4 = H, halogen, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, (3-8C)cycloalkyl(1-6C)alkyl, OH, 1-6C alkoxy, benzyloxy 2-6C alkenyloxy, 2-6C alkynyloxy, CN, CF3, OCF3, NO2, OSO2CF3, OSO2Me, NHCOMe, NHCOCF3, NHSO2Me, NR1R2 or CONR1R2; R1, R2 = H, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, aryl(1-6C)alkyl or (3-8C)cycloalkyl(1-6C)alkyl; X = O, SOp, (CH2)n or CH2YCH2; p = 0-2; n = 1-4; Y = O, Se, SOp, NR1 or CR1R2; A = (CH2)mQ; Q = NR1R2, 4,5-dihydro-2-oxazolylamino or 4,5-dihydro-1H-imidazol-2-ylamino; m = 1-6. An Independent claim is also included for the preparation of (I).