AMINE DERIVATIVE FIXED TO RESIN AND METHOD FOR SYNTHESIZING beta -AMINOCARBONYL COMPOUND IN A SOLID PHASE

摘要

An imine fixed to a resin characterized in that it is represented by the following formula: P-Q-N=CH-R wherein P represents a main chain of a polymer constituting the resin, Q represents a hydrocarbon side chain optionally substituted with a substituent which may be bonded via a heteroatom and R represents an optionally substituted hydrocarbon group or a heterocyclic group, and a beta -aminocarbonyl compound fixed to a resin represented by formula (II) are provided. The beta -aminocarbonyl compound fixed to a resin is a beta -aminocarbonyl compound being handled in a solid form. An amine fixed to a resin which is a key compound for a solid state synthesis of this type and represented by the following formula: P-Q1-O-Q2-NH2, wherein Q1 and Q2 are each a hydrocarbon chain selected from among an arylene group, an alkylarylene group and an arylenealkylene group, is also provided, which allows the synthesis of beta -aminocarbonyl compound by application of an iminoaldol reaction in a solid phase.