ENHANCEMENT OF INTRACELLULAR DELIVERY AND TISSUE TARGETING OF DRUGS AND GENES
摘要
A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intracellular target specifically recognized by the antibody.
申请公布号
WO9945960(A1)
申请公布日期
1999.09.16
申请号
WO1999US05279
申请日期
1999.03.10
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;MUZYKANTOV, VLADIMIR, R.;ALBELDA, STEVEN, M.
