METHODS FOR PREVENTING AND TREATING FIBROTIC DISEASES RESULTING FROM ACCUMULATION OF EXCESS EXTRACELLULAR MATRIX INDUCED BY TGF beta USING RENIN INHIBITORS

摘要

The present invention is methods for inhibiting the renin-induced production of TGF beta using a renin inhibitory agent to reduce excess accumulation of extracellular matrix in tissue in a subject, and to the use of renin inhibitory agents and additional TGF beta inhibitory agents to reduce TGF beta production to treat and prevent fibrotic diseases.