| 摘要 |
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus. The treatment is effected by providing to the infection target a n amount of antibody, or antibody binding fragment, which binds specifically to RNAIII activating protein (RAP) which upregulates expression of virulence factors by a Staphylococcus infection in said host, or by raising a protective immune response in said host in the form of a circulating antibody titre through administration of RAP, or a fragment thereof, which promotes the expression of antibodies thereto by said host, which antibodies bind RAP and inhibit its ability to upregulate the virulence factors.
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