| 发明名称 |
INHIBIDORES DE PROTEASAS |
| 摘要 |
The invention relates to 3-hydroxy- and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy- or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
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| 申请公布号 |
PE71599(A1) |
申请公布日期 |
1999.09.15 |
| 申请号 |
PE19980000336 |
申请日期 |
1998.05.05 |
| 申请人 |
SMITHKLINE BEECHAM P.L.C.;SMITHKLINE BEECHAM CORPORATION |
发明人 |
MARQUIS, ROBERT W.;VEBER, DANIEL F.;GRIBBLE, ANDREW D.;WITHERINGTON, JASON;FENWICK, ASHLEY EDWARD |
| 分类号 |
C07D307/22;C12N9/99;A61K31/34;A61K31/341;A61K31/35;A61K31/351;A61K31/36;A61K31/38;A61K31/381;A61K31/443;A61K31/4709;A61P1/02;A61P19/00;A61P19/02;A61P19/10;C07D307/32;C07D307/33;C07D307/83;C07D307/86;C07D309/14;C07D309/30;C07D333/36;C07D405/12;C07D407/12;C07D409/12 |
主分类号 |
C07D307/22 |
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