| 摘要 |
Provided are compositions comprising soluble IL-2R alpha molecules (tsIL-2R alpha ) produced and shed by metastatic cells; nucleic acid molecules encoding tsIL-2R alpha , vectors for expressing tsIL-2R alpha ; assay kits for detecting and quantitating the amount of tsIL-2R alpha in a sample; and methods for detecting and quantitating the amount of tsIL-2R alpha that may be present in a body fluid of an individual. A method for detecting the presence or absence of tsIL-2R alpha in a body fluid of an individual comprises obtaining a sample of body fluid from the individual; contacting the sample with an affinity ligand which binds to an epitope on tsIL-2R alpha ; and detecting the amount of tsIL-2R alpha bound to the affinity ligand. |
