Use of skin penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response induced by adp-ribosylating exotoxin

摘要

Disclosed is a formulation comprising an antigen and an adjuvant for transcutancous immunization of a subject, wherein the antigen induces an immune response specific for the antigen following application of the formulation to the subject's unperforated skin which is treated to disrupt the stratum corneum.