发明名称 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents
摘要 <p>Compounds according to the formula: &lt;CHEM&gt; wherein: R1 and R2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R3 and R4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and &lt;CHEM&gt; wherein: each R5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R5 groups together represent C2 to C10 alkyl, hydroxyalkyl, or alkylene; and R6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, lkylaminoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a pharmaceutically acceptable salt thereof, are disclosed. The compounds are useful for treating Pneumocystis carinii in a subject in need of such treattment.</p>
申请公布号 EP0941991(A1) 申请公布日期 1999.09.15
申请号 EP19980305895 申请日期 1998.07.23
申请人 UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;GEORGIA STATE UNIVERSITY 发明人 BOYKIN, DAVID W.;FRANCESCONI, IRIS;WILSON, DAVID W.;TIDWELL, RICHARD R.
分类号 A61K31/34;A61K31/341;A61P11/00;A61P29/00;A61P33/02;C07D307/52;C07D307/54;C07D405/10;C07D405/14;(IPC1-7):C07D307/54;A61K31/415 主分类号 A61K31/34
代理机构 代理人
主权项
地址