发明名称 |
Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods |
摘要 |
Adjuvant formulations are provided containing quaternary ammonium salts in conjunction with an oil component which may be a mineral oil, an animal oil, a vegetable oil, a mixture thereof, or an oil-in-water emulsion of one or more of such oils. These formulations are useful in conjunction with known immunological substances, e.g., viral or bacterial antigens in a vaccine composition, in order to enhance the immunogenic response. The compositions are also useful without an incorporated antigen as nonspecific immunostimulatory formulations.
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申请公布号 |
US5951988(A) |
申请公布日期 |
1999.09.14 |
申请号 |
US19950463837 |
申请日期 |
1995.06.05 |
申请人 |
UNIVERSITY OF SASKATCHEWAN |
发明人 |
LITTEL-VAN DEN HURK, SYLVIA VAN DRUNEN;ZAMB, TIMOTHY;REDMOND, MARK J. |
分类号 |
A61K39/39;A61P37/04;(IPC1-7):A61K39/00;A61K45/00 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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