发明名称 |
Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2a] indolcarboxcyclic acids and their activated derivatives |
摘要 |
The invention relates to a process and intermediates for the preparation of enantiomerically pure cycloalkanoindolecarboxylic acids and azaindolecarboxylic acids and pyrimido[1,2a]indolecarboxylic acids and their activated derivatives, characterized in that the tolyl acetic acid is first esterified with a chiral alcohol, then diastereoselective substitution at alpha -carbon atoms is carried out and this product is halogenated in the tolyl group and then reacted with appropriate cycloalkanoindoles, cycloalkanoazaindoles or pyrimido[1,2a]indoles. It is possible by this method to prepare specifically, in high purity, the enantiomerically pure carboxylic acids which are intermediates for valuable medicaments.
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申请公布号 |
US5952498(A) |
申请公布日期 |
1999.09.14 |
申请号 |
US19970829566 |
申请日期 |
1997.03.31 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
LENFERS, JAN-BERND;FEY, PETER;NAAB, PAUL;VAN LAAK, KAI |
分类号 |
C07C69/612;C07C69/616;C07C69/65;C07D471/04;C07D487/04;(IPC1-7):C07D471/04 |
主分类号 |
C07C69/612 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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