发明名称 |
Tetrahydroisoquinoline derivatives |
摘要 |
The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula wherein A is aryl R1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R-CO- or R-COO-, wherein R is lower alkyl; R2 is hydrogen, lower alkyl or cycloalkyl R3-R7 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy or R3 and R4 taken together are -(CH2)n- or R6 and R7 taken together are -OCH2O- and n is 3 or 4, as well as pharmaceutically acceptable salts for the manufacture of medicaments for the control or treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers.
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申请公布号 |
US5952344(A) |
申请公布日期 |
1999.09.14 |
申请号 |
US19980008724 |
申请日期 |
1998.01.19 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
ALANINE, ALEXANDER;BOURSON, ANNE;BUETTELMANN, BERND;FISCHER, GUENTHER;NEIDHART, MARIE-PAULE HEITZ;MUTEL, VINCENT;PINARD, EMMANUEL;ROEVER, STEPHAN;TRUBE, GERHARD;WYLER, RENE |
分类号 |
C07D217/16;A61K31/47;A61K31/472;A61K31/473;A61K31/4741;A61P25/00;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/26;A61P25/28;A61P43/00;C07D217/18;C07D217/20;C07D217/24;C07D221/00;C07D221/06;C07D221/12;C07D491/04;C07D491/056;(IPC1-7):A61K31/47 |
主分类号 |
C07D217/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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