发明名称 |
Tris carbamic acid esters: inhibitors of cholesterol absorption |
摘要 |
Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholesterol and thus can lower serum cholesterol levels. Compounds of the formula: where Z is or -Ar1-(CR=CR)1-3-Ar2, -AR1-NR7-AR2 and A is a linking group inhibit the enzymes CEH and/or ACAT (in vitro) and inhibit absorption of cholesterol.
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申请公布号 |
US5952354(A) |
申请公布日期 |
1999.09.14 |
申请号 |
US19930095140 |
申请日期 |
1993.07.21 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
COMMONS, THOMAS JOSEPH;STRIKE, DONALD PETER;LACLAIR, CHRISTA MARIE |
分类号 |
C12N9/99;A61K31/40;A61K31/4427;A61K31/443;A61K31/445;A61P3/00;A61P3/04;A61P3/06;A61P9/10;A61P43/00;C07D211/16;C07D211/46;C07D211/62;C07D401/12;C07D405/14;(IPC1-7):A61K31/445;C07D211/36 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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