Preparation and use of alpha -(hydroxyimino) phosphonoacetic acids

摘要

alpha -(hydroxyimino)phosphonoacetic acids (also referred to as " alpha , alpha -disubstituted trifunctional oximes" and "Troika Acids") and their derivatives, and methods to prepare them are disclosed. Also disclosed are the structures and fragmentation pathways of the alpha -(hydroxyimino)phosphonoacetic acids. The alpha -(hydroxyimino)phosphonoacetic acids and derivatives are useful as pH sensitive chelating agents, enzyme activated drugs, drug delivery agents, phosphorylating reagents and photo-activated reagents.