REDOX AMINO ACIDS AND PEPTIDES CONTAINING THEM

摘要

The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine ~ pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.