发明名称 |
Tropane analogs and methods for inhibition of monoamine transport |
摘要 |
New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.
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申请公布号 |
US5948933(A) |
申请公布日期 |
1999.09.07 |
申请号 |
US19970893921 |
申请日期 |
1997.07.11 |
申请人 |
ORGANIX, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
MELTZER, PETER C.;MADRAS, BERTHA K.;BLUNDELL, PAUL;CHEN, ZHENGMING |
分类号 |
A61K31/18;A61K31/198;A61K31/35;A61K31/405;A61K31/46;A61K38/00;A61K51/04;A61P25/00;A61P25/30;A61P43/00;C07C33/34;C07C41/00;C07C49/105;C07C49/115;C07C69/74;C07C69/753;C07C205/00;C07C233/00;C07C255/00;C07D311/00;C07D451/02;C07D451/06;C07D471/08;C07D493/08;C07F7/22;(IPC1-7):C07C255/00 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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地址 |
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