发明名称 |
Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits |
摘要 |
Novel peptides capable of interacting with a hydrophobic structural determinant on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.
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申请公布号 |
US5948763(A) |
申请公布日期 |
1999.09.07 |
申请号 |
US19960630645 |
申请日期 |
1996.04.10 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
SOTO-JARA, CLAUDIO;BAUMANN, MARC H.;FRANGIONE, BLAS |
分类号 |
G01N33/566;A61K38/00;A61K49/00;A61P25/28;C07K5/097;C07K7/08;C07K14/47;G01N33/68;(IPC1-7):A61K38/00 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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