发明名称 |
Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics |
摘要 |
The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.
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申请公布号 |
US5948389(A) |
申请公布日期 |
1999.09.07 |
申请号 |
US19970922573 |
申请日期 |
1997.09.03 |
申请人 |
EL KHOURY & STEIN, LTD. |
发明人 |
STEIN, CHRISTOPH |
分类号 |
A61K9/00;A61K9/08;A61K9/10;A61K47/00;(IPC1-7):A61K9/10 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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